In recent years a variety of major international research has produced compelling evidence that sitting for more than 4 hours each day leads to:

Enzymes responsible for burning harmful blood fats shutting down
Reduced calorie burning (Metabolic rate)
Disrupted blood sugar levels
Increased insulin and blood pressure levels
Leg muscles switch off
 
Irrespective of your level of physical activity, the result leads to increased risks of:

1. Heart disease
2. Diabetes
3. Obesity
4. Cancer
5. Back ache
6. Dementia
7. Depression
8. Muscle degeneration
 
To calculate the hours you spend sitting on an average “working day” & what action you can take go to: http://getaustraliastanding.org/